Starting a business in New York City can be quite challenging due to its highly competitive market and high cost of living. The initial investment needed for rent, permits, and licenses can be overwhelming for aspiring entrepreneurs. Additionally, navigating the complex regulations and tax structures can be time-consuming and frustrating. However, the city also offers a vast network of resources and potential clients, which can help businesses thrive. Overall, the difficulties of starting a business in NYC can be outweighed by the opportunities it presents for growth and success.